(no subject)
Jun. 19th, 2002 09:04 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
the_rckWell, I've not been feeling well for a while now. It's looking at this point like it's probably "just" stress. I've been having a lot of trouble eating, nausea, poor appetite, mood swings and generally feeling rotten. At first I thought I might be pregnant, but a blood test and my period have shown that that's not the case. Given that it's been going on for two and a half weeks without changing, it seems unlikely to be a virus. It started about five days after we changed one of my medications, but changing back has had no effect (and any problems with that particular med are supposed to end within 4 days of making the change). I had more tests done yesterday just in case it's my liver or something like that, but… I think we're going to end up calling it stress by default.
Speaking of my medications, I finally talked to that clinic in Seattle about carisoprodol during pregnancy. There's one study about it in mice. At 11 to 34 times "normal" dosage, there were no effects on the offspring, but there were birth defects when it was given at doses that caused maternal toxicity.
There's a hitch, however. Carisoprodol metabolizes into something called meprobamate. It, also, doesn't have much done in the way of studies during pregnancy, and what there is is contradictory. There are about half a dozen studies total. The larger cohort studies show no correlation to any problems at all, but the smaller studies (30-60 subjects) each show a correlation with a completely different birth defect if used in the first trimester of pregnancy. The clinic's "panel of experts" rated the risk during the first trimester as "minimal" but said they couldn't discount the small studies entirely.
∆
Speaking of my medications, I finally talked to that clinic in Seattle about carisoprodol during pregnancy. There's one study about it in mice. At 11 to 34 times "normal" dosage, there were no effects on the offspring, but there were birth defects when it was given at doses that caused maternal toxicity.
There's a hitch, however. Carisoprodol metabolizes into something called meprobamate. It, also, doesn't have much done in the way of studies during pregnancy, and what there is is contradictory. There are about half a dozen studies total. The larger cohort studies show no correlation to any problems at all, but the smaller studies (30-60 subjects) each show a correlation with a completely different birth defect if used in the first trimester of pregnancy. The clinic's "panel of experts" rated the risk during the first trimester as "minimal" but said they couldn't discount the small studies entirely.
∆
